Biophysical Instrumentation Core
The Biophysical Instrumentation Core Facility is equipped with state of the art instrumentation to aid researchers in characterizing molecular interactions, sample integrity, stability, structure, and more. The Core is open to both internal and external users.
- Fluorescence and Fluorescence Anisotropy
- Circular Dichroism (CD) and Linear Dichroism (LD) spectroscopy
- Absorbance Spectroscopy
- Binding Affinity (KD)
- Dynamic Light Scattering (DLS) and Multi-Angle Light Scattering (MALS)
- Surface Plasmon Resonance (SPR)
- Isothermal Titration Calorimetry (ITC)
- Differential Scanning Calorimetry (DSC)
All instruments are located in the same location on the UMass Boston campus in the Integrated Sciences Complex (ISC). Our facility is accessible by public transportation (T) with also parking nearby. Supported by the Massachusetts Life Sciences Center.
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Jasco FP-8350
- Monitor protein and nucleic acid secondary structure
- Determine Tm values for heat denaturation
- Quantify sample concentrations
- Binding affinity (KD) determination
Kinetics
- Fluorescence and Fluorescence Anistropy
- 4-cell holder, thermostated for temperature control and thermal melt experiments
- Microvolume (5 uL) attachment for protein and nucleic acids
More details at the Jasco site